![]() Clinical challenges of immune checkpoint inhibitors. Combinatorial approaches with checkpoint inhibitors to enhance anti-tumor immunity. Next-generation immuno-oncology agents: current momentum shifts in cancer immunotherapy. Pan C, Liu H, Robins E, Song W, Liu D, Li Z, et al. Cancer immunotherapy using checkpoint blockade. Papers of particular interest, published recently, have been highlighted as: Perceptive strategies aimed at modulating the TIME, regardless of STK11 status or specifically addressed to STK11-mutated cases, will hopefully provide valid therapeutic options to be adopted in the clinical practice. IT approaches available thus far in NSCLC, mainly represented by anti-PD-1/PD-L1 inhibitors, are not promising in the case of STK11 inactivation. The physiologic regulation of multiple cellular pathways performed by STK11 likely explains the multifaceted modifications in tumor cells, stroma, and tumor immune microenvironment (TIME) observed in STK11 mutant lung cancer, particularly explored in the molecular subgroup of KRAS co-mutation. On the other hand, waiting for prospective and solid data, the putative negative predictive value of STK11 inactivation towards IT is sustained by less evidence. After a thorough literature review, STK11 mutations condition the prognosis of NSCLC patients receiving ICI-containing regimens, implying a relevant biological and clinical significance. STK11 mutations have been globally labeled as markers of IT resistance. ![]() In non-small-cell lung cancer (NSCLC) patients, besides PD-L1 expression evaluation with its intrinsic limitations, tissue and circulating parameters, likely portraying the tumor and its stromal/immune counterparts, have been proposed as potential predictors of IT responsiveness. The quest for immunotherapy (IT) biomarkers is an element of highest clinical interest in both solid and hematologic tumors.
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![]() These are located just under the signal light switch. By referring to the picture (click) you will be able to see that there is a bearing (which seldom ever goes bad, just clean and relube it) and a plastic or rubber insulator around it. When this one is bad you may experience the ability to move the steering wheel up and down, the steering wheel may rub on the signal light collar on the column or you may feel a roughness when turning the steering wheel and this roughness you feel will seem to be right in the steering wheel. The other item is the Insulator around the upper bearing in the column. The shaft should be held in place at all times by the fact that it is solidly mounted to the steering sector by the rubber coupler. It should also be noted that the Nylon Centering Cone at the bottom of the steering shaft does no more than keep the dirt out of the bottom of the column and serve as a cushion if the column or sector move enough to let the shaft bump against the side of the tube. So maybe one doesn't have to remove the column to replace this bugger after all. Guess what? Its still there after 7 years and working fine. I cut one of the bushings at what would be the bottom, snapped it over the shift tube and pushed it into place. By looking at it, I could see that the column would have to come out to do the job properly. I have a '64 Bird and when I was getting it ready for the road in 1991, I found I had a bad bushing. John, I wanted to let you know about my experience with steering column bushings and see what you thought. (If you do not have one, refer to the pictures on this site or you can order a shop manual by sending me an email). If you have a shop manual you can refer to that. In order to replace the bushing you need to remove the steering column from the car and disassembled. If the shift lever fix doesn't solve most of your troubles then it is time to open the hood and find the shif tube and check to see if the bushing is bad. The lever will not register correctly as to what gear you are in and you will also have trouble getting the car into park and low. If this is bad or gone you will have trouble trying to shift your car. One is the Nylon bushing at the lower end of the shift tube. There are a couple items in your steering column that can cause trouble. Put the lever back in and your problem should be nearly all solved. Take this to a welding shop and have them weld it up and grind it down so that it matches the rest of the area near it. You will see that there is a one eighth inch notch worn into the flat part of the lever. ![]() You can repair this easily by pounding out the roll pin that holds the shift lever into the collar on the steering column and pulling out the shift lever. If you are having trouble keeping your shift lever in the proper postion and it won't stay in park, the problem, more than likely is that the shift lever itself has a notch worn into it down on the end inside the steering column. Rebuilding the seat foam in the 1958-60 Birdsħ7-79 Strut rod bushing washer installation Headliner Replacement in Town Landau and Town Coupeįoamy Steering Fluid / Growling Noise / Air in System Shift Lever Fix-It for all Thunderbirds from '58 thru 1966 ![]() In no way are we saying that the shows of the present lack in the above fields but the re-watchability factor is missing from most of them. Despite them being like chalk and cheese, the commonalities between these two super hit series have to be a good mix of the above three. If we were to derive a formula or state reasons for why these series will remain popular till eternity, it would have to be - cast, script and direction. From big names paying their tributes to the cast - David Schwimmer, Jennifer Aniston, Courteney Cox, Lisa Kudrow, Matt LeBlanc and Matthew Perry, Gunther’s video call appearance (Who knew it would be his last! RIP) to revelations like Jen and David’s off-screen attraction and LeBlanc dislocating his shoulder for real while filming, it was something that fans couldn’t help but discuss for months. The reunion special of our favourite sitcom was a grand celebration. As revealed in the reunion, FRIENDS has been watched over 100 billion times across all platforms. Many experts even concluded that this is one show that helped boost mental health and helped with anxiety. I can guarantee that anyone who has watched the show couldn’t help but re-watch it over and over again. Ross, Rachel, Monica, Chandler, Phoebe and Joey became an integral part of our lives and remained so even after the show ended. The entertainment that this show provided couldn’t be contested. Despite all its flaws, it made for good TV that helped in de-stressing and taking off our load. ![]() Prime video If you rewind a bit, the FRIENDS era was something that indulged everyone. In fact, the reunion was so mind-boggling that it definitely warranted for a 70MM screening (Screw you, COVID). ![]() The two-hour special showed us many facets and never-heard-before details, that most of us absorbed with disbelief and awe! Just when we thought there couldn’t be any more detail that could take us by surprise, we were hit with several intricate ones.īe it Tom Felton (Draco Malfoy) and Emma Watson’s cute crush-turned-friendship, Daniel Radcliffe’s harmless inclination towards much-older Helena Bonham Carter aka Bellatrix Lestrange or behind-the-scenes bits of iconic moments, this ride was worth every penny. It was much later in 2001, when we could visualise the story in the form of a movie that was the beginning of it all.Ģ0 years later, Daniel Radcliffe (Harry Potter), Rupert Grint (Ron Weasley) and Emma Watson (Hermione Granger) sat down to talk about how it wasn’t just the fans but even their life changed with this film series. Taking a deeper dive into it, Harry Potter came into our lives in the year 1997 when author JK Rowling introduced us to the wizarding world with her first book 'Harry Potter and the Philosopher's Stone'. Was there a hit formula that the makers complied to? Well, it’s difficult to say but what we do know is that it was a sort of an extraordinary connect that kept us hooked for life. On one hand, we had a series like Harry Potter which had a humongous visual appeal along with fantabulous plotlines and on the other, we had a simple yet entertaining sitcom like FRIENDS which braved the storm for 10 long years and still left the audiences yearning for more for decades that followed. ( I would have included the beloved Game Of Thrones but after the finale hoopla most of us gave up!) Series/shows are dime a dozen these days but have there been any that could skyrocket and become a phenomena like a Harry Potter or FRIENDS? Of course, the answer is subjective but we all know that none of the recent ones could even reach halfway. In fact, they were a simple sit across the table and reminisce about the golden moments kind. As the buzz around Harry Potter 20th Anniversary: The Return To Hogwarts lingers, it won’t be wrong to say that the power of nostalgia remains unbeatable.Ĭome to think of it, be it the people of the wizarding world or our ‘FRIENDS’ from the late 90s -00s, these reunions weren’t over-the-top or trying-too-hard-to-look-cool walk down memory lane. Generally, men have more muscle mass, while women tend to have higher fat mass. Since men and women differ greatly in body composition, it immediately affects a person’s ideal BFP. What is the Right Body Fat Percentage (BFP)?Ī person’s ideal body fat percentage depends on several factors, including their gender, age, and height. Finally, we’ll discuss how to achieve the right fat percentage for improved health. In this guide, we’ll talk about the ideal body fat percentage for men and women, risks of low or excess fat mass, and different ways you can measure your body fat. To estimate your body fat percentage, use our calculator above. This is why it’s important to keep track your weight, especially your body fat mass. And as with everyone, if you don’t watch what you eat, it will eventually take its toll on your health. It’s easy to get carried away when you have access to epicurean feasts. However, passion for food does not always translate to a healthy diet. ![]() Somewhere along the way, taking control of your diet can also help you develop healthier food choices. As a culinary enthusiast, you benefit by learning how to prepare all sorts of delicious meals. Achieving Your Ideal Body Fat Percentageīeing passionate about food directly affects your nutrition and health. Before using the data obtained using this calculator, please consult with doctor. Next you'll use the following formula, to calculate the voltage drop across the feeders. 6 AWG stranded copper wire has a resistance of 0.491 ohms per 1000 ft. In your case, 8 AWG stranded copper wire has a resistance of 0.778 ohms per 1000 ft. The first step here will be to use Table 8 from chapter 9 of the NEC, to determine the resistance of the conductors you've selected. Once you have the base conductor size selected, you'll want to calculate the voltage drop across that size conductors for the length of the feeders. If you want a 60 ampere panel, you'll need 6 AWG copper conductors. So in your case, if you want to install a 50 ampere panel, you'll need at least 8 AWG copper conductors. For your situation, we'll assume we can use the 75☌ column, that you want to use copper conductors, and there's no other corrections required. Start out by using Table 310.15(B)(16), and applying any required corrections, to determine what size conductors you'll need. Also, if you answer can you please give a reference to the part of the NEC that you are referencing? I plan to have an electrician do most the work so for now I just need to know what size conduit to drop in the ground. I'm know the length of the run will impact wire gauge and that in turn will dictate the conduit size due to fill constraints. It is another 60 feet underground through the yard, and 10 feet inside the garage to the sub-panel. It is 60 feet from main panel through crawl space. The run will start at the main panel at front of house, dip into the crawl space, run to the back of the house, dip underground and travel to the garage, then run to the sub-panel in the garage. The run will be 1 phase 240V and go from a 100amp main panel and travel 130 feet to a 50amp sub-panel. Right now I am trenching the underground portion of the run and need to know what size PVC 80 conduit to install in the trench. ![]() The plan is to remove the overhead wires and install a new sub-panel in the garage with an underground (PVC 80) run between the house and garage. I have old overhead wires that go between my home and a detached garage. A severe case, along with precipitating factors like cold weather and infections, can cause myxedema. ![]() The longer hypothyroidism is left untreated, the less the body is able to cope. Meditation can help one attain mental peace. It releases endorphins―feel-good hormones―that help one feel physically and emotionally better. Regular exercise can relieve stress, reduce symptoms of depression, and help maintain a healthy lifestyle. Patients are also concerned about fertility issues they should know that these medicines do not cause any harm but rather help in the successful pregnancy of those with thyroid disorders.Īlong with medication, a few lifestyle measures can improve the way your immune system functions, and can help control the symptoms of hypothyroidism. If given in optimum quantities as prescribed by the physician, it does not affect any organ, but rather improves the patient's quality of life. They should be assured that life-long intake of thyroxine in hypothyroid patients is a natural replacement of the deficient hormone. Many patients are afraid that taking thyroid medication all their lives may adversely affect their organs, especially the heart and bones. It is important that patients take their prescribed medication and do regular thyroid tests and follow-up visits with their doctor. Hypothyroidism is generally a life-long condition. Further tests may also estimate the total thyroxine (T4) or free thyroxine (FT4) in the body. That is because the pituitary gland produces more TSH to stimulate the thyroid gland into producing more thyroid hormones. ![]() A low level of thyroxine and high level of TSH indicate an under-active thyroid. TSH tests are the most accurate screening method for primary hypothyroidism and are widely available. ![]() The diagnosis of hypothyroidism is based on the symptoms and results of blood tests that measure the level of TSH, or the thyroid-stimulating hormone. When the thyroid produces less hormone, you may experience symptoms like fatigue, loss of energy, weight gain, intolerance to cold, dry skin, hair loss, pain in joints and muscles, depression, emotional stress, mental impairment, impaired memory, inability to concentrate, constipation, disturbed menstrual cycle, sexual dysfunction, nerve entrapment syndromes, blurred vision and fullness in throat. Compared with coastal cities (Mumbai, Goa, and Chennai), land-locked ones (Kolkata, Delhi, Ahmedabad, Bengaluru and Hyderabad) have a higher prevalence (11.7 per cent vs 9.5 per cent). In India, it is 11 per cent, compared with only 2 per cent in the UK and 4.6 per cent in the US. According to NHANES III (National Health and Nutrition Examination Survey), the overall prevalence of hypothyroidism is 4.6 per cent globally. The gland’s hormone production slows down which, in turn, slows your metabolism.Īge affects the likelihood of getting hypothyroidism more older people have it than youngsters. Hypothyroidism is a common condition where the thyroid does not create and release enough T3 (Tri-iodothyronine) and T4 (thyroxine) into the bloodstream. If not treated on time, it can lead to cardiovascular symptoms like the slowing of heart rate, constriction of blood vessels, increased blood pressure and cholesterol levels, retention of fluid and oedema. Hypothyroidism may lead to a disturbance in the metabolic system resulting in unintentional weight loss/weight gain, fatigue or irregular heartbeat. ![]() When her condition started to deteriorate, she went for a checkup and found that her cholesterol levels had increased, and that she had developed hypothyroidism and high blood pressure. Like so many others, her hectic schedule made her put off her annual health checkup. ROHINI, 35, was experiencing weight gain, tiredness, dry skin, hair loss and joint pain. ![]() ![]() Super Mario 3D World + Bowser's Fury (2021) Various, most notably a carpenter and a plumberĬontrol over fire and some other elements,Ĭranky Kong (also known as Donkey Kong Sr.) (formerly), Pauline (also known as The Lady) (ex-girlfriend),ĭonkey Kong the Third (ally, son figure and rival) Mario Mario (according to Super Mario Bros.: The Movie ) Mario's artwork from the game New Super Mario Bros. If you have a relevant image for this article, Seriously.This article is in need of additional or higher-quality images. On top of being downright amazing, the game is an important piece of its franchise, its genre, and gaming history in general. With hidden secrets, endless surprises, and overflowing charm, it’s easy to see why Donkey Kong Country enjoys such a stellar legacy. The sights and sounds are incredible, the controls are solid and deliberate, and levels are varied and unforgiving. You don’t know sweaty palms until you’re on your last life at the last checkpoint of a particularly stressful level, just one or two well-timed jumps away from making your progress permanent.ĭonkey Kong Country is a formulaic 2D platformer, but it gets every bit of that formula right. Even simple platforming comes with loads of pressure when one more death will send you four levels backward. This means that, upon entering a new world, the player normally has to beat three or four levels without losing all of their lives before they reach a save point. You can only save at designated checkpoints in each of the game’s six worlds. To add to the intensity, Donkey Kong Country utilizes an old-fashioned limited save system. Jolt after jolt of adrenaline flow through your veins in the speedy danger of the famous minecart levels. Several levels spice things up by having you take command of rhinos, ostriches, giant fish, and more. Its levels are deep and challenging, filled to the brim with ruthless platforming, cruel enemies, and hidden secrets that you will find yourself going back for again and again and again. Donkey Kong Country is a treat for the ears and eyes.Īside from looking and sounding great, Donkey Kong Country is very, very fun. The musical prowess deserves reiteration as well classic tracks like Aquatic Ambience appear here in overflowing glory for the first time. Donkey Kong Country is very pretty, with a unique graphical style that sets it apart from its 16-bit brethren. Levels pop with bright backgrounds and glorious musical arrangements. Its toe-tapping opening tune embeds itself in your head instantaneously, and from there, you’re launched into a vibrant, stimulating world. You owe it to yourself to check it out.ĭonkey Kong Country wastes no time in asserting itself as a colorful, engrossing game. Donkey Kong Country is a fantastic title and an intriguing piece of gaming history. Finally, the immensely amazing game asserted itself, and later, its sequels, as a new major figure in the 2D platformer genre. Formerly a simple simian who kidnapped women and stood on top of construction projects, his 2D platforming adventure spawned the energetic, mischievous, playful family of Kongs that we all know and love today. For its titular character, Donkey Kong, the game completely reinvented his personality. For its developer, Rare, the first Donkey Kong Country represented a new era of quality from the studio as a partner to Nintendo. With its tight controls, treacherous level design, a catchy soundtrack, and lovely retro graphics, Donkey Kong Country marked a few important beginnings in video games. Once you have changed the settings under Encoding, reset the Advanced settings. If you continue to experience lagging, lower the FBS to 30. Select video from the sidebar menu and adjust Custom settings to 1280×720.In Max Bitrate field, enter 800,000 (If you continue to experience lagging, increase the Max bitrate).Settings to change on computer with 720p resolution: If you still experience lagging, lower the FPS to 30. Select video from the sidebar menu and adjust Custom settings to 1920 x 1080.Set Max Bitrate (kb/s) field to 500,000.Visit Settings > Encoding (in the sidebar menu).Settings to change on computer with 1080p resolution: You can fix the OBS video freeze and lagging issue by changing to these settings in the OBS. You may have to play around with its settings until you find the one which works the best on your system.īelow is the preferred setting for 1080p and 720p computer resolution. OBS recording settings vary with every computer. At times when the network issue cannot be fixed, lowering bitrate is helpful. Lowering bitrate stops the issue of dropped frames, thus preventing video lagging in OBS. If you drop too many frames, you may lose connection with the server. ![]() Streamers tend to use higher bitrate to enhance video quality but this leads to dropped frames. Streaming on a wired connection is better and assures continuous network. Disconnect from your router and connect the computer directly to the modem using Ethernet cable. Wireless connections are not always stable or continuous. Fix or change them, if you find them loose or damaged. Faulty Ethernet cable, port, or router may interfere in the smooth playing of OBS videos. When trying to fix lagging in OBS, do not ignore the hardware issue. Watch video how to repair corrupt OBS videos by using Stellar Repair for Video The software supports repair of AVI, ASF, WMV, MKV, FLV, DIVX, WEBM, MJPEG, MPEG, AVCHD, MTS, MOV, MP4, M4V, 3G2, 3GP, and F4V files. Using this software, you can effectively fix video streaming issues like lagging, jerkiness, and other types of corruptions. The tool is well-equipped to fix any kind of corruption in the OBS videos. If the recorded OBS videos are lagging or freezing it is recommended to use a professional video repair tool – Stellar Repair for Video. Contact your service provider to fix the speed and network issue, if any. Check your connection speed using any speed test tool. Dropped frames means your connection is not stable. ![]()
Don't put off printing out your digital memories when you can print them for less with ink cartridges from Printerinks. Our Free Next-day UK delivery makes it even easier to get the prints you love at a great price you'll appreciate. We also sell original HP cartridges for less than you'd pay elsewhere, so you can be sure you are getting the best UK price, guaranteed. Remanufactured ink cartridges are better for the environment and your wallet, as they cost less but provide the same great quality of their original counterparts. deals for HP Photosmart 375 compact Photo Printer New With Ink And Paper at the best online. Printerinks has a wide selection of high quality remanufactured HP ink cartridges for use in your HP PhotoSmart 375, so you can save money and still get the great prints you love. Premium pick: HP Sprocket Studio 4圆 Instant Photo Printer. The cost of ink can put some people off of printing out their own photos, but that doesn't have to be a problem if you use a smarter solution. With HP's photo printers, there's a lot to love, except for maybe the price of the ink cartridges themselves. ![]() At the touch of a button, you can bring your digital memories to life in gorgeous full colour and high detail, and share them with your friends and family within minutes. After all, it combines the fantastic quality of an HP printer with the easy to use function of a portable photo printer, and it's great for use anywhere, anytime. ![]() If you love taking pictures with your digital camera, but hate how complicated some photographic printers are to use, you probably adore your HP PhotoSmart 375. As well as our online file conversion service, we also offer a desktop app for file conversions straight from your desktop, and an API for automated file conversions for developers. We offer a range of tools, to help you convert your files in the most convenient way for you. 100 free, secure and easy to use Convertio advanced online tool that solving any problems with any files. I highly recommend SumatraPDF or MuPDF if you're after something a bit more. From your personal desktop to your business files, we've got you covered. Best way to convert your PS to PDF file in seconds. You may or may not need an add-on or extension to do it, but it's pretty handy to have one open automatically when you click a PDF link online. Right-click your selection and choose Quick Export As image format from the context menu. Select the layers, layer groups, or artboards you want to export. prn extension instead. Most web browsers, like both Chrome and Firefox, can open PDFs themselves. To access the Quick Export As option, do either of the following: Navigate to File > Export > Quick Export As image format. Give a PostScript file the same name as the original document, but with the extension. ![]() It's completely fine to use, but I find it to be a somewhat bloated program with lots of features that you may never need or want to use. Adobe created the PDF standard and its program is certainly the most popular free PDF reader out there. Most people head right to Adobe Acrobat Reader when they need to open a PDF. ![]() ![]() PDF files always look identical on any device or operating system. The reason PDF is so widely popular is that it can preserve original document formatting. Check the Preview box in the dialogue box to see what the bleed area. The Portable Document Format (PDF) is a universal file format that comprises characteristics of both text documents and graphic images which makes it one of the most commonly used file types today. Go to the File dropdown menu and select Document Setup Select Bleed and Slug Enter. |
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